Bioorganic & medicinal chemistry letters

Naphthalimide intercalators with chiral amino side chains: Effects of chirality on DNA binding, photodamage and antitumor cytotoxicity

Q Yang, P Yang, X Qian, L Tong

Index: Yang, Qing; Yang, Peng; Qian, Xuhong; Tong, Lianpeng Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6210 - 6213

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Citation Number: 36

Abstract

Several novel heterocyclic-fused naphthalimides intercalators with chiral amino side chains were investigated. Their side chains' chiral configuration determines DNA binding activities in the order: S-enantiomers> R-enantiomers. And their DNA photodamaging activities were in good agreement with their DNA binding constants, the S-enantiomers could photocleave circular supercoiled pBR322 DNA more efficiently than their R-enantiomers. S-enantiomer ...

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