Thiourea-based gemfibrozil analogues as HDL-elevating agents

…, JB Eskesen, DS France, JR Paterniti

Index: Coppola, Gary M; Damon, Robert E; Eskesen, J Bruce; France, Dennis S; Paterniti Jr., James R Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 17 p. 2439 - 2442

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Citation Number: 9

Abstract

A series of gemfibrozil analogues with a thiourea moiety embedded in the side chain was prepared and evaluated as HDL-elevating agents. Derivatives 8b, 9b, 9c, and 9d were found to be approximately as effective as gemfibrozil (1) for HDL cholesterol elevation. ... A series of gemfibrozil analogues with a thiourea moiety embedded in the side chain was prepared and evaluated as HDL-elevating agents. Derivatives 9b, 9c, and 9d were approximately as effective as gemfibrozil for HDL ...