Synlett

The Synthesis of 6-Deazaformycin A

T Tite, N Lougiakis, P Marakos, N Pouli

Index: Tite, Tony; Lougiakis, Nikolaos; Marakos, Panagiotis; Pouli, Nicole Synlett, 2009 , # 18 p. 2927 - 2930

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Citation Number: 2

Abstract

Abstract The synthesis of the new C-nucleoside 6-deazaformycin A was achieved through the condensation of a suitably substituted lithiated 2-picoline with 2, 3, 5-tri-O-benzyl-d- ribonolactone, borohydride reduction of the resulting hemiacetals, followed by intramolecular Mitsunobu cyclization of the carbinols, manipulation of the protecting groups, and subsequent ring closure to result in the formation of 7-amino-3-(β-d-ribofuranosyl) ...