2, 3-Pyridine annulation. The enantioselective synthesis of an aldose reductase inhibitor

…, SW Goldstein, SL Pezzullo, GJ Quallich…

Index: Murtiashaw, Charles W.; Breitenbach, Ralph; Goldstein, Steven W.; Pezullo, Susan L.; Quallich, George J.; Sarges, Reinhard Journal of Organic Chemistry, 1992 , vol. 57, # 6 p. 1930 - 1933

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Citation Number: 11

Abstract

This present methodology, therefore, appears to be novel and has greater synthetic utility than the procedures available thus far, since the easily available permanganate ion has been utilized to obtain some not 80 easily acceasible 5&6@-epoxides of AS-unsaturated steroids in high yields under very mild reaction conditions. The study of the mechanism of this reaction and the origin of ita high stereoselectivity are presently under investigation.