Synthesis of a C8 oxygenated pyranonaphthoquinone: a useful precursor to dimeric pyranonaphthoquinones

P Bachu, J Sperry, MA Brimble

Index: Bachu, Prabhakar; Sperry, Jonathan; Brimble, Margaret A. Tetrahedron, 2008 , vol. 64, # 15 p. 3343 - 3350

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Citation Number: 13

Abstract

The class of compounds known as the pyranonaphthoquinone antibiotics are isolated from various strains of bacteria and fungi, the majority being microbial in origin. 1 and 2 This family of compounds have been shown to exhibit activity against various Gram-positive bacteria, pathogenic fungi and yeasts, as well as antiviral activity. Several pyranonaphthoquinones have also been proposed to act as effective bioreductive alkylating agents. 3 and 4 More structurally complex ...