Syntheses of Idarubicin Analogues Containing a Glucose or Galactose Moiety as a Glycone

YS Rho, R Park, SY Kim, DJ Yoo

Index: Rho, Young S.; Park, Ran; Kim, Seon-Young; Yoo, Dong Jin Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 1 p. 69 - 74

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Citation Number: 7

Abstract

The new idarubicin analogues (12 and 13) with a glucose or galactoseas as a glycone were synthesized from daunomycin (2).(+)-4-Demethoxydaunomycinone (6) obtained from reaction of 2with AlCl3 was converted to 4-trifluoromethanesulfonyl daunomycinone (7) through reaction with trifluoromethanesulfonic anhydride. The treatment of 7 with 1, 1-bis- (diphenylphospino) ferrocene/Pd (OAc) 2 in triethylamine/formic acid/dioxane provided ...