The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates

E Marzi, J Gorecka, M Schlosser

Index: Marzi, Elena; Gorecka, Joanna; Schlosser, Manfred Synthesis, 2004 , # 10 p. 1609 - 1618

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Citation Number: 8

Abstract

Abstract 2, 4-Difluorophenol, 2, 5-difluorophenol, 2, 3-difluorophenol, 3, 5-difluorophenol, 3, 4-difluorophenol, 2, 4, 5-trifluorophenol and 2, 3, 4-trifluorophenol were converted into all 18 possible di-or trifluorinated hydroxybenzoic acids (1a-c, 4a-c, 9a-c, 12a, b, 14a-c, 17a, b, 18a, b), all of them new compounds. The phenolic hydrogen atom was replaced by a methoxymethyl or, less frequently, by a triisopropylsilyl group, which exerted an ortho ...