Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity
M Anwar, AR Cowley, MG Moloney
Index: Anwar, Muhammad; Cowley, Andrew R.; Moloney, Mark G. Tetrahedron Asymmetry, 2010 , vol. 21, # 13-14 p. 1758 - 1770
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Citation Number: 18
Abstract
The synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may provide a useful template for fragment-based drug design providing rapid access to novel antibacterial compound libraries.
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