A long-range chiral relay via tertiary amide group in asymmetric catalysis: new amino acid-derived N, P-ligands for copper-catalysed conjugate addition

AV Malkov, JB Hand, P Kočovský

Index: Malkov, Andrei V; Hand, John B; Kocovsky, Pavel Chemical communications (Cambridge, England), 2003 , # 15 p. 1948 - 1949

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Citation Number: 4

Abstract

New N, P-ligands 4–6, derived from valinol and prolinol, respectively, have been developed for the asymmetric, copper (I)-catalysed conjugate addition of diethylzinc to unsaturated ketones; the tertiary amide group has been shown to effectively relay the chiral information from the ligand backbone to the active centre.