Minor groove hydration is critical to the stability of DNA duplexes

T Lan, LW McLaughlin

Index: Lan, Tao; McLaughlin, Larry W. Journal of the American Chemical Society, 2000 , vol. 122, # 27 p. 6512 - 6513

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Citation Number: 50

Abstract

Since the original observation of an ordered set of water molecules, 1, 2 termed the “spine of hydration,” within the primary hydration sphere of the minor groove of duplex B-form DNA, numerous studies have concentrated upon the function and role-(s) of minor groove hydration. In the described spine of hydration, individual water molecules bridge the N3- nitrogens of adenines and the O2-carbonyls of thymines at adjacent base pairs. A second ...