Expanding the scope and orthogonality of PNA synthesis

S Pothukanuri, Z Pianowski…

Index: Pothukanuri, Srinivasu; Pianowski, Zbigniew; Winssinger, Nicolas European Journal of Organic Chemistry, 2008 , # 18 p. 3141 - 3148

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Citation Number: 16

Abstract

Abstract Peptide nucleic acids (PNAs) hybridize to natural oligonucleotides according to Watson and Crick base-pairing rules. The robustness of PNA oligomers and ease of synthesis have made them an attractive platform to encode small or macromolecules for microarraying purposes and other applications based on programmable self assembly. A cornerstone of these endeavors is the orthogonality of PNA synthesis with other ...