A study on the Z-selective Horner-Wadsworth-Emmons (HWE) reaction of methyl diarylphosphonoacetates

K Kokin, KI Iitake, Y Takaguchi, H Aoyama…

Index: Kokin, Keisuke; Iitake, Ken-Ichro; Takaguchi, Yutaka; Aoyama, Hiromu; Hayashi, Sadao; Motoyoshiya, Jiro Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 133, p. 21 - 40

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Citation Number: 9

Abstract

Abstract Experimental and theoretical studies were conducted to explore the Z-selectivities in the Homer-Wadsworth-Emmons (HWE) reaction employing several methyl diarylphosphonoacetates (3, 4, 5 and 6) and aldehydes. The Z-selectivity depended upon the reaction conditions such as the bases, reaction temperature, and the aromatic suhstituents on the phosphorus atoms but the almost phosphonoacetates used in the ...