A New Synthesis of 2-Aryl-4-hydroxyquinolines1

RC Fuson, DM Burness

Index: Fuson; Burness Journal of the American Chemical Society, 1946 , vol. 68, p. 1270

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Citation Number: 26

Abstract

It has been discovered that 2-aryl-4-hydroxyquinolines can be made conveniently and in satisfactory yields by heating an anthranilic acid or its ester with the acetal of an alkyl aryl ketone. For example, when ethyl anthranilate was heated in phenyl ether with slightly more than an equimolecular amount of the diethyl acetal of acetophenone, 4-hydroxy-2- phenylquinoline (I) was formed in a yield of S4%.