A Remarkably Faster Approach Towards 1, 2, 3-Triazolyl Quinolines Via CuAAC in Water: Their Crystal Structure Analysis and Antibacterial Activities

…, N Yadagiri Sreenivasa Murthy, S Pal

Index: Mareddy, Jyoti; Shanthi Praveena, Koduru Sri; Suresh, Nallapati; Jayashree, Anireddy; Roy, Soma; Rambabu, Dandela; Sreenivasa Murthy, Nandula Yadagiri; Pal, Sarbani Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 343 - 352

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Citation Number: 3

Abstract

A series of 1, 2, 3-triazolyl quinolines possessing substituents like–CH2OAr (Ar= aryl) moiety on the triazolyl ring were synthesized via a multi-step sequence consisting of copper- catalyzed azide-alkyne cycloaddition (CuAAC) of 3-(azidomethyl)-quinoline derivative with terminal alkynes as a key step. This step was found to be remarkably faster in pure water and completed within 10-45 min. The robustness of this step was demonstrated by ...