Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects

…, MW Smith, SK Schlachter, CF Lawson…

Index: TenBrink; Bergh; Duncan; Harris; Huff; Lahti; Lawson; Lutzke; Martin; Rees; Schlachter; Sih; Smith Journal of Medicinal Chemistry, 1996 , vol. 39, # 13 p. 2435 - 2437

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Citation Number: 67

Abstract

Migraine headache is a debilitating, chronic disease affecting the lives of millions of people worldwide. 1, 2 Migraine is most prevalent in working age populations (35-40 years old), and its economic impact in the United States alone has been estimated in the billions of dollars. 3, 4 Currently, the primary treatment for migraine is Sumatriptan (1), a nonselective serotonergic agent which binds with high affinity to both the 5-HT1D and 5-HT1B ...