Solvent-free synthesis of 2-amino-4-arylthiazoles under microwave irradiation

D Cáceres-Castillo, RM Carballo, JA Tzec-Interián…

Index: Caceres-Castillo, David; Carballo, Ruben M.; Tzec-Interian, Jorge A.; Mena-Rejon, Gonzalo J. Tetrahedron Letters, 2012 , vol. 53, # 30 p. 3934 - 3936

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Citation Number: 11

Abstract

It is well known that thiazole derivatives are important compounds in medicinal chemistry 1 due to their broad range of biological activities. This type of heterocycles have shown a wide variety of pharmacoactive properties as anti-inflammatory, 2 anti-tubercular, 3 anti-bacterial, 4 fungicidal, 5 local anaesthetic, 6 tranquilizers, 7 insecticidal, 8 anti-microbial, 9 anti-tumor 10 and diuretic. 11 Considerable efforts have been devoted to the synthesis of this type of ...