Synthesis of 5-hydroxy-2, 3, 4, 5-tetrahydro-[1 H]-2-benzazepin-4-ones: selective antagonists of muscarinic (M 3) receptors

B Bradshaw, P Evans, J Fletcher, ATL Lee…

Index: Organic and Biomolecular Chemistry, , vol. 6, # 12 p. 2138 - 2157

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Citation Number: 16

Abstract

... Chem., 2008, 6, 2138-2157 Show Compounds Show Chemical Terms Show Biomedical Terms. ... This chemistry was then used to prepare the 2-[(N-arylmethyl)aminoalkyl analogues 69, 72, 76 ... Indeed, the lithiated dithiane also reacted with the Weinreb amide 6 to give ketone 12. ...