Synthesis and antitumor evaluation of a novel series of triaminotriazine derivatives

…, F Du, H Liu, L Lin, C Li, J Ding, K Chen, H Jiang

Index: Zheng, Mingfang; Xu, Chenghui; Ma, Jianwei; Sun, Yan; Du, Feifei; Liu, Hong; Lin, Liping; Li, Chuan; Ding, Jian; Chen, Kaixian; Jiang, Hualiang Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 4 p. 1815 - 1827

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Citation Number: 34

Abstract

A series of triaminotriazine derivatives (compounds 5a–f, 6a–x, and 7a–g) was designed, synthesized, and evaluated for their inhibition activities to colorectal cancer (CRC) cell lines (HCT-116 and HT-29). Most of the synthesized compounds demonstrated moderate anti- proliferatory effects on both HCT-116 and HT-29 cell lines at the concentration of 10μM. The inhibitory activities against HCT-116 and HT-29 cell lines were discussed to develop the ...