Molecules

Consecutive three-component synthesis of 3-(Hetero) aryl-1H-pyrazoles with propynal diethylacetal as a three-carbon building block

L Levi, C Boersch, CF Gers, E Merkul, TJJ Müller

Index: Levi, Lucilla; Boersch, Christina; Gers, Charlotte F.; Merkul, Eugen; Mueller, Thomas J. J. Molecules, 2011 , vol. 16, # 11 p. 9340 - 9356

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Citation Number: 7

Abstract

Abstract A novel consecutive three-component synthesis of 3-(hetero) aryl-1H-pyrazoles via room temperature Sonogashira arylation of propynal diethylacetal used as a propargyl aldehyde synthetic equivalent has been disclosed. The final acetal cleavage- cyclocondensation with hydrazine hydrochloride at 80 C rapidly furnishes the title compounds in a one-pot fashion. Keywords:

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