Tetrahedron Letters

Synthesis of functionalized benzothiophenes by twofold Heck and subsequent 6π-electrocyclization reactions of 2, 3-dibromothiophene

…, M Hussain, I Malik, A Villinger, P Langer

Index: Toguem, Serge-Mitherand Tengho; Hussain, Munawar; Malik, Imran; Villinger, Alexander; Langer, Peter Tetrahedron Letters, 2009 , vol. 50, # 35 p. 4962 - 4964

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Citation Number: 23

Abstract

In the recent years, it has been shown that polyhalogenated heterocycles can be regioselectively functionalized in palladium(0)-catalyzed cross-coupling reactions by selective activation of a single halogen atom. The regioselectivity is controlled by electronic and steric parameters. 6 Recently, we have reported the synthesis of aryl-substituted thiophenes, 7 pyrroles, 8 and selenophenes 9 based on regioselective Suzuki reactions of tetrabromothiophene, tetrabromo-N- ...