Enzymatic kinetic resolution studies of racemic 4-hydroxycyclopent-2-en-1-one using Lipozyme IM®
…, VA Mahajan, UR Kalkote, T Ravindranathan
Index: Ghorpade, Sandeep R.; Bastawade, Kulbhushan B.; Gokhale, Digambar V.; Shinde, Popat D.; Mahajan, Vishal A.; Kalkote, Uttam R.; Ravindranathan Tetrahedron Asymmetry, 1999 , vol. 10, # 21 p. 4115 - 4122
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Citation Number: 26
Abstract
Enzymatic kinetic resolution studies of (±)-4-hydroxycyclopent-2-en-1-one 2 were taken up in organic solvents by transesterification with vinyl acetate and alcoholysis of its acetate 3 as an alternative to the desymmetrization of meso-cyclopentenediol to provide faster and economic access to enantiomerically pure 4-(R)-tert-butyldimethylsilyloxycyclopent-2-en-1- one 1. Parameters were screened using Lipozyme IM® as catalyst. Although ...
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