Metabolism of genistein by rat and human cytochrome P450s

ES Roberts-Kirchhoff, JR Crowley…

Index: Roberts-Kirchhoff, Elizabeth S.; Crowley, Jan R.; Hollenberg, Paul F.; Kim, Hyesook Chemical Research in Toxicology, 1999 , vol. 12, # 7 p. 610 - 616

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Citation Number: 61

Abstract

The metabolism of genistein (4', 5, 7-trihydroxyisoflavone), a phytoestrogen derived from soy products, was investigated using rat and human liver microsomes and recombinant human cytochrome P450 enzymes. Metabolism of genistein by microsomes obtained from rats treated with pyridine, phenobarbital, β-naphthoflavone, isosafrole, pregnenolone-16α- carbonitrile, or 3-methylcholanthrene resulted in very different product profiles consisting ...