Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

SC Mayer, AL Banker, F Boschelli, L Di…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 12 p. 3641 - 3645

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Citation Number: 43

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... focused library arrays were instrumental in moving these investigations through the Wyeth exploratory medicinal chemistry process. ... 1)]. 8 Along with chemical triage and data-mining, input from structural biology helped to fully ...