Discovery of 14??3??3 Protein–Protein Interaction Inhibitors that Sensitize Multidrug??Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693

…, J Dinić, R Hill, M Rossi, D Colecchia, M Pešić…

Index: Mori, Mattia; Vignaroli, Giulia; Cau, Ylenia; Dinic, Jelena; Hill, Richard; Rossi, Matteo; Colecchia, David; Pesic, Milica; Link, Wolfgang; Chiariello, Mario; Ottmann, Christian; Botta, Maurizio ChemMedChem, 2014 , vol. 9, # 5 p. 973 - 983

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Citation Number: 9

Abstract

Abstract 14-3-3 is a family of highly conserved adapter proteins that is attracting much interest among medicinal chemists. Small-molecule inhibitors of 14-3-3 protein–protein interactions (PPIs) are in high demand, both as tools to increase our understanding of 14-3- 3 actions in human diseases and as leads to develop innovative therapeutic agents. Herein we present the discovery of novel 14-3-3 PPI inhibitors through a multidisciplinary strategy ...