Cyclopropylamines from N, N??Dialkylcarboxamides and Grignard Reagents in the Presence of Titanium Tetraisopropoxide or Methyltitanium Triisopropoxide
A De Meijere, V Chaplinski, H Winsel…
Index: Kordes, Markus; Winsel, Harald; De Meijere, Armin European Journal of Organic Chemistry, 2000 , # 18 p. 3235 - 3245
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Citation Number: 15
Abstract
Abstract Thirty-three different N, N-dialkyl-and N-alkyl-N-phosphorylalkyl-substituted carboxamides 9–17 were treated with unsubstituted as well as with 2-alkyl-, 2, 2-dialkyl-, and 3-alkenyl-substituted ethylmagnesium bromides 6 in the presence of stoichiometric amounts of titanium tetraisopropoxide or methyltitanium triisopropoxide to furnish substituted cyclopropylamines 20–25 in 20–98% yield, depending on the substituents with no (1: 1) to ...
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