Synthesis and flow cytometric evaluation of novel 1, 2, 3, 4-tetrahydroisoquinoline conformationally constrained analogues of nitrobenzylmercaptopurine riboside ( …
Z Zhu, J Furr, JK Buolamwini
Index: Zhu, Zhengxiang; Furr, John; Buolamwini, John K. Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 831 - 837
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Citation Number: 25
Abstract
Novel regioisomers of conformationally constrained analogues of the potent es nucleoside transporter ligand, nitrobenzylmercaptopurine riboside (NBMPR), designed for probing its bound (bioactive) conformation, were synthesized and evaluated as es transporter ligands by flow cytometry. Purine 6-position 5, 6, 7, or 8-nitro-1, 2, 3, 4-tetrahydroisoquinolylpurine ribosides, in which the nitrobenzyl moiety in NBMPR has been locked into the nitro-1, 2, 3, ...
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