2-Amino-5-aryl-pyridines as selective CB 2 agonists: Synthesis and investigation of structure–activity relationships

…, D Livermore, A Moses, NH Nicholson, LW Page…

Index: Gleave, Robert J.; Beswick, Paul J.; Brown, Andrew J.; Giblin, Gerard M.P.; Haslam, Carl P.; Livermore, David; Moses, Andrew; Nicholson, Neville H.; Page, Lee W.; Slingsby, Brian; Swarbrick, Martin E. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6578 - 6581

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Citation Number: 10

Abstract

2-Amino-5-aryl-pyridines, exemplified by compound 1, had been identified as a synthetically tractable series of CB2 agonists from a high-throughput screen of the GlaxoSmithKline compound collection. Described herein are the results of an investigation of the structure– activity relationships (SAR) which led to the identification a number of potent and selective agonists.