Cross??Coupling Reactions of Organosilicon Compounds in the Stereocontrolled Synthesis of Retinoids

J Bergueiro, J Montenegro, F Cambeiro…

Index: Bergueiro, Julian; Montenegro, Javier; Cambeiro, Fermin; Saa, Carlos; Lopez, Susana Chemistry - A European Journal, 2012 , vol. 18, # 14 p. 4401 - 4410

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Citation Number: 15

Abstract

Abstract This paper presents a full account of the use of Hiyama cross-coupling reactions in a highly convergent approach to retinoids in which the key step is construction of the central C10 [BOND] C11 bond. Representatives of two families of oxygen-activated dienyl silanes (ethoxysilanes and silanols) and of all reported families of “safety-catch” silanols (siletanes, silyl hydrides, allyl-, benzyl-, aryl-, 2-pyridyl-and 2-thienylsilanes) were regio-and ...