Bulletin of the Chemical Society of Japan
Total synthesis of antibiotic althiomycin.
K Inami, T Shiba
Index: Inami; Shiba Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 1 p. 352 - 360
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Citation Number: 38
Abstract
Total Synthesis of antibiotic althiomycin has been achieved starting from D-cysteine. The imide bond between thiazoline and the pyrrolinone part was constructed by coupling reaction of sodium salt of pyrrolinone with cysteine active ester or by photoreaction with diketene. The hydroxymethyl group attached on the carbon adjacent to C-2 of the thiazoline ring, was introduced by aldol condensation posterior to the thiazoline ring formation. The ...