Lipase catalyzed synthesis of macrocyclic lactones in organic solvents
A Makita, T Nihira, Y Yamada
Index: Makita, Atushi; Nihira, Takuya; Yamada, Yasuhiro Tetrahedron Letters, 1987 , vol. 28, # 7 p. 805 - 808
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Citation Number: 126
Abstract
Abstract A new method for the preparation of macrocyclic lactones from ω-hydroxyacid methyl esters is described. The approach utilizes intramolecular transesterification catalyzed by lipase in organic solvents. This procedure is also applicable to the synthesis of asymmetric lactones.
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