Tetrahedron

Preparation of novel 3H-trifluoromethyldiazirine-based photoactivatable potassium channel antagonists

JM Sanderson, JBC Findlay, CWG Fishwick

Index: Sanderson, John M.; Findlay, John B. C.; Fishwick, Colin W. G. Tetrahedron, 2005 , vol. 61, # 47 p. 11244 - 11252

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Citation Number: 9

Abstract

The preparation of a series of photoactivatable precursors for use in photoaffinity labelling of potassium channels is described. 3H-Diazirine functionalities were incorporated into the previously described potassium channel antagonists. The ability to perform enantioselective reductions and Wittig reactions in the presence of 3H-diazirines was central to this work.