Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1′-{6-[5-(pyridin-3-ylmethyl)-1, 3, 4-oxadiazol-2-yl] pyridazin-3-yl}-3, 4-dihydrospiro [ …

…, M Konishi, T Takagi, S Wakimoto, J Ohsumi

Index: Uto, Yoshikazu; Ueno, Yuko; Kiyotsuka, Yohei; Miyazawa, Yuriko; Kurata, Hitoshi; Ogata, Tsuneaki; Yamada, Makiko; Deguchi, Tsuneo; Konishi, Masahiro; Takagi, Toshiyuki; Wakimoto, Satoko; Ohsumi, Jun European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 4788 - 4796

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Citation Number: 23

Abstract

In continuation of our investigation on novel stearoyl-CoA desaturase (SCD) 1 inhibitors, we have already reported on the structural modification of the benzoylpiperidines that led to a series of novel and highly potent spiropiperidine-based SCD1 inhibitors. In this report, we would like to extend the scope of our previous investigation and disclose details of the synthesis, SAR, ADME, PK, and pharmacological evaluation of the spiropiperidines with ...