An improved manufacturing process for the antimalaria drug coartem. Part II

U Beutler, PC Fuenfschilling…

Index: Organic Process Research and Development, , vol. 11, # 3 p. 341 - 345

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Citation Number: 27

Abstract

... 2. Current Manufacturing Procedure for 2. ... The organic layer is cooled to 0 °C, and compound 8 is isolated by filtration and drying. ... 3.2. Optimized Process Conditions for the Manufacture of 2. The condensation of intermediate 8 with p-chlorobenzaldehyde in the presence of ...