Condensation of lactams with 2-aminoacetylaldehyde diethyl acetal. A one-pot synthesis of bicyclic imidazoles

…, F Zhang, J Chen, PD Robinson

Index: Hua, Duy H.; Zhang, Fengqi; Chen, Jinshan; Robinson, Paul D. Journal of Organic Chemistry, 1994 , vol. 59, # 17 p. 5084 - 5087

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Citation Number: 36

Abstract

Although many efforts have been devoted to the synthesis of imidaz0 [1, 2-a] pyridines, 3,~ the synthesis of 5, 6, 7, 8-tetrahydroimidazo [l, 2-alpyridines and other 1, 2-fused bicyclic imidazoles (such as 2) have not been reported. Inspired by the condensation method developed at the Sagami Chemical Research Centel. 5 for the preparation of 2-substituted imidazoles, consisting of simply heating amides with 2-aminoacetaldehyde dimethyl ...