Asymmetric alkylations of a sultam-derived glycinate equivalent: practical preparation of enantiomerically pure α-amino acids
W Oppolzer, R Moretti, S Thomi
Index: Oppolzer, Wolfgang; Moretti, Robert; Thomi, Silvia Tetrahedron Letters, 1989 , vol. 30, # 44 p. 6009 - 6010
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Citation Number: 130
Abstract
Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Deprotonation/alkylation of sultam-derived N-[bis(methyl)thiomethylene]glycinate equivalent gave crystalline products which on mild hydrolysis furnished α-amino acids (~100% ee) in high overall yield. ... Deprotonation/alkylation/mild hydrolysis 3 → 5 → 7 gave α-amino acids ...
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[Tetrahedron Letters, , vol. 30, # 44 p. 6009 - 6010]