Mapping the aspartic acid binding site of Escherichia coli asparagine synthetase B using substrate analogs

…, SK Boehlein, AB Dribben, SM Schuster…

Index: Parr, Ian B.; Boehlein, Susan K.; Dribben, Anthony B.; Schuster, Sheldon M.; Richards, Nigel G. J. Journal of Medicinal Chemistry, 1996 , vol. 39, # 12 p. 2367 - 2378

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Citation Number: 32

Abstract

Novel inhibitors of asparagine synthetase, that will lower circulating levels of blood asparagine, have considerable potential in developing new protocols for the treatment of acute lymphoblastic leukemia. We now report the indirect characterization of the aspartate binding site of Escherichia coli asparagine synthetase B (AS-B) using a number of stereochemically, and conformationally, defined aspartic acid analogs. Two compounds, ...