Synthesis and radiosynthesis of a novel PET Fluorobenzyl piperazine for melanoma tumour imaging;[18F] MEL054

…, T Bourdier, P Roselt, A Katsifis, I Greguric

Index: Taylor, Stephen R.; Roberts, Maxine P.; Wyatt, Naomi A.; Pham, Tien Q.; Stark, Daniela; Bourdier, Thomas; Roselt, Peter; Katsifis, Andrew; Greguric, Ivan Australian Journal of Chemistry, 2013 , vol. 66, # 4 p. 491 - 499

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Citation Number: 2

Abstract

Abstract 2-{2-[4-(4-[18 F]-Fluorobenzyl) piperazin-1-yl]-2-oxoethyl} isoindolin-1-one ([18 F] MEL054), is a new potent indolinone-based melanin binder designed to target melanotic tumours.[18 F] MEL054 was prepared by an automated two-step radiosynthesis, comprising of the preparation of 4-[18 F] fluorobenzaldehyde from 4-formyl-N, N, N-trimethylanilinium triflate, followed by reductive alkylation with 2-(2-oxo-2-piperazin-1-ylethyl) isoindolin-1- ...