Studies on the biosynthesis of the antibiotic reductiomycin in Streptomyces xanthochromogenus
…, C Graff, U Mocek, A Nakagawa, S Omura…
Index: Cho; Beale; Graff; Mocek; Nakagawa; Omura; Floss Journal of the American Chemical Society, 1993 , vol. 115, # 26 p. 12296 - 12304
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Citation Number: 31
Abstract
Abstract: The biosynthesis of the antibiotic reductiomycin (1) in Streptomyces xanthochromogenus was investigated by feeding experiments with radioactive and stable isotope-labeled precursors. NMR and mass spectroscopic analyses of the labeled 1 samples revealed that the acetoxy group comes from acetate, the 2-amino-3- hydroxycyclopent-2-enone moiety arises by a novel intramolecular cyclization of 5- ...
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