Convenient Synthesis of 1H??Indol??1??yl Boronates via Palladium (0)??Catalyzed Borylation of Bromo??1H??indoles with 'Pinacolborane'

JF Stadlwieser, ME Dambaur

Index: Stadlwieser, Josef F.; Dambaur, Markus E. Helvetica Chimica Acta, 2006 , vol. 89, # 5 p. 936 - 946

Full Text: HTML

Citation Number: 19

Abstract

Abstract An atom-economic Pd 0-catalyzed synthesis of a series of pinacol-type indolylboronates 3 from the corresponding bromoindole substrates 2 and pinacolborane (pinBH) as borylating agent was elaborated. The optimal catalyst system consisted of a 1: 2 mixture of [Pd (OAc) 2] and the ortho-substituted biphenylphosphine ligand L-3 (Scheme 4, Table). Our synthetic protocol was applied to the fast, preparative-scale synthesis of 1- ...