Efficient Selective Formation of C??C Single Bonds and C˭ C Double Bonds by NBS??Promoted Oxidative Coupling of β??Keto Esters

Z Wang, G Yin, A Chen, S Hu, A Wu

Index: Wang, Zhiguo; Yin, Guodong; Chen, Aihua; Hu, Shengli; Wu, Anxin Synthetic Communications, 2007 , vol. 37, # 24 p. 4399 - 4405

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Citation Number: 6

Abstract

Abstract A new application of NBS, which results in the oxidative coupling of β??keto esters to selectively form C??C single and C˭ C double bonds, can be controlled by the amount of NBS and t??BuOK employed. This methodology adds a new entry to C??C single and C˭ C double??bond formation between active methylene groups under mild conditions with high selectivity.