A convenient method for the synthesis of phosphorothioates and their anticholinesterase activities

B Kaboudin, S Emadi, H Norouzi

Index: Kaboudin, Babak; Emadi, Saeed; Norouzi, Hamid Phosphorus, Sulfur and Silicon and the Related Elements, 2004 , vol. 179, # 3 p. 585 - 590

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Citation Number: 3

Abstract

A simple, efficient, and general method has been developed for the synthesis of phosphorothioates through a one-pot reaction of alkyl halides with the mixture of diethyl phosphite in the presence of NH 4 OAc/S/CaO under solvent–free conditions. The anticholinesterase activities of eight different phosphorothioates were investigated on acetylcholinesterase from electric eel.