Preparation of unsymmetrical biaryls via Ni-or Pd-catalyzed coupling of aryl chlorides with arylzincs
JA Miller, RP Farrell
Index: Miller, Joseph A.; Farrell, Robert P. Tetrahedron Letters, 1998 , vol. 39, # 36 p. 6441 - 6444
Full Text: HTML
Citation Number: 88
Abstract
Unsymmetrical biaryls may be prepared in an efficient manner using aryl chlorides as substrates in Negishi-type cross-coupling reactions with arylzinc reagents via either Ni-or Pd- catalysis. Since a wide range of functional groups (eg, nitrile, carbonyl, ester) tolerate arylzinc compounds, this methodology allows for the direct synthesis of biaryls from aryl chlorides possessing these moieties.
Related Articles:
An efficient and cost-effective synthesis of 2-phenyl-3-aminopyridine
[Caron, Stephane; Massett, Steve S.; Bogle, David E.; Castaldi, Michael J.; Braish, Tamim F. Organic Process Research and Development, 2001 , vol. 5, # 3 p. 254 - 256]
An efficient and cost-effective synthesis of 2-phenyl-3-aminopyridine
[Organic Process Research and Development, , vol. 5, # 3 p. 254 - 256]
[Synthesis, , vol. 2012, # 2 p. 290 - 296]
[Organic Letters, , vol. 16, # 4 p. 1260 - 1263]