Amino acid analogs III: New syntheses of monomethyl??and monophenylglutamic acids

…, R Parmegiani, VR Giannasio, IS Krull

Index: Gershon; Parmegiani; Giannasio; Krull Journal of Pharmaceutical Sciences, 1975 , vol. 64, # 11 p. 1855 - 1858

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Citation Number: 5

Abstract

Abstract Glutamic acid analogs containing 3-and 4-methyl and 2-, 3-, and 4-phenyl substituents were prepared. The 3-and 4-methyl-and 3-and 4-phenylglutamic acids did not inhibit Plasmodium berghei and were nontoxic to the host (mice) at 640 mg/kg. The five analogs in addition to 2-methylglutamic acid were inactive against Lactobacillus casei at 1000 μg/ml in a defined medium; against Escherichia coli, only 2-methylglutamic acid ...