Synthesis of 3-methoxyestra-1, 3, 5 (10), 6-tetraen-17-one

…, JC Ferrer, C Malet, JM Amezaga

Index: Brosa; Ferrer; Malet; Amezaga Journal of Organic Chemistry, 1989 , vol. 54, # 16 p. 3984 - 3985

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Citation Number: 11

Abstract

4 5 in pyridine, via the procedure reported by Alvarez and Watt? gave 4 in only 3% yield. Previous workers' had already shown that Corynebacterium simplex could be used to effect aromatization by the microbial dehydrogenation of certain 19-nor-A4-3-ketosteroids. When 3 was submitted to this transformation, the phenol 4, equal in all aspects to authentic sample, was isolated in 74% yield. Finally 4 was reacted to dimethyl sulfate and potassium ...