Nature Chemistry

Triflimide-catalysed sigmatropic rearrangement of N-allylhydrazones as an example of a traceless bond construction

DA Mundal, CT Avetta Jr, RJ Thomson

Index: Mundal, Devon A.; Avetta Jr., Christopher T.; Thomson, Regan J. Nature Chemistry, 2010 , vol. 2, # 4 p. 294 - 297

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Citation Number: 28

Abstract

The recognition of structural elements (that is, retrons) that signal the application of specific chemical transformations is a key cognitive event in the design of synthetic routes to complex molecules. Reactions that produce compounds without an easily identifiable retron, by way of either substantial structural rearrangement or loss of the atoms required for the reaction to proceed, are significantly more difficult to apply during retrosynthetic planning, ...