Receptor Interactions of Synthetic Morphiceptin Analogs Containing Phenylalanine Homologs in Position 4.

…, T Costa, H Sakamoto, Y Shimohigashi

Index: Sakaguchi; Costa; Sakamoto; Shimohigashi Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 4 p. 1052 - 1056

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Citation Number: 3

Abstract

A series of phenylalanine homologs with elongated phenylalkyl side chains (R=–(CH 2) nC 6 H 5, n= 1–4) have been incorporated into opioid peptide morphiceptin at position 4 in order to elucidate a role of the amino acid residue in the molecular mechanism of receptor activation. The receptor specificity and selectivity of peptides synthesized were examined in the radio-ligand receptor binding assays using tritiated DAGO-and DADLE-enkephalins.[ ...