Australian Journal of Chemistry

Synthesis of some substituted 4-aminobut-2-enoic acids as analogues of the neurotransmitter GABA

RD Allan, B Twitchin

Index: Allan,R.D.; Twitchin,B. Australian Journal of Chemistry, 1978 , vol. 31, p. 2283 - 2289

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Citation Number: 10

Abstract

Abstract Allylic bromination of a series of α, β-unsaturated acids with N-bromosuccinimide gave crude products which could be aminated conveniently in liquid ammonia to prepare the substituted 4-aminobut-2-enoic acid (4-aminocrotonic acid) derivatives (4a-f) in low to moderate yields. The assignment of the trans configuration of the carboxyl and aminomethyl groups about the double bond of the amino acid products is supported by chemical ...