Synthesis and selective M-cholinoblocking activity of tetraamines. Part II

…, TL Gorchakova, VV Dolgo-Saburov…

Index: Bespalov; Gorchakova; Dolgo-Saburov; Kuznetsov; Kosmachev; Libman; Podosinovikova; Ramsh; Shelkovnikov Pharmaceutical Chemistry Journal, 1997 , vol. 31, # 7 p. 361 - 364

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Abstract

In the previous communication [I ] we have described an original method for the synthesis of tetraamines of type I, in which the methylene groups in radical B are partly replaced by aromatic fragments: ... It was demonstrated that these substances possess a selec- tive affinity to the M2 subtype of cholinoreceptors [I], and it was established that at least one of the synthesized com- pounds [XIII: Ar=Ph, A=(CH2)6, B = 1,4-C6H4(CH2)2] was superior in selectivity as ...