Synthesis, pH-dependent, and plasma stability of meropenem prodrugs for potential use against drug-resistant tuberculosis

…, A Meissner, RA Harding, CA Wong, CC Aldrich…

Index: Teitelbaum, Aaron M.; Meissner, Anja; Harding, Ryan A.; Wong, Christopher A.; Aldrich, Courtney C.; Remmel, Rory P. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5605 - 5617

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Citation Number: 8

Abstract

Abstract Meropenem, a broad-spectrum parenteral β-lactam antibiotic, in combination with clavulanate has recently shown efficacy in patients with extensively drug-resistant tuberculosis. As a result of meropenem's short half-life and lack of oral bioavailability, the development of an oral therapy is warranted for TB treatment in underserved countries where chronic parenteral therapy is impractical. To improve the oral absorption of ...