A Versatile Route to Functionalized Dilactones as Monomers for the Synthesis of Poly (α??hydroxy) Acids

…, MJ van Uxem, CF van Nostrum…

Index: Leemhuis, Mark; Van Steenis, Jan Hein; Van Uxem, Michelle J.; Van Nostrum, Cornelus F.; Hennink, Wim E. European Journal of Organic Chemistry, 2003 , # 17 p. 3344 - 3349

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Citation Number: 34

Abstract

Abstract A synthetic pathway to functionalized six-membered dilactones structurally analogous to lactide is described. Through the use of orthogonal protecting groups, the synthesis of functionalized dilactones was performed in a straightforward way by cyanuric chloride-mediated cyclization of the corresponding linear α-hydroxy acid dimers. The synthesis of three different dilactones− methylglycolide, benzyloxymethylglycolide, and 2- ...